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Tuesday, August 01, 2006

Alzheimer's Vaccine from Mice!?

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An exciting new vaccine has been found to be promising in preventing plaque formation in mice, one of the major causes of Alzheimer’s disease. These plaques are known as amyloid protein plaques. This novel form of a vaccine would be a preventative treatment for Alzheimer’s disease, stopping it before it ever began.

The vaccine works to stimulate the immune system to see the plaques as foreign to the body, and the immune system then attacks and destroys the plaques.

What is even more exciting about this vaccine is that it was found to have no side effects in the mice, unlike a previous vaccine the same research group had been working on. The previous vaccine was found to potentially cause swelling or inflammation of the brain. But, this newer vaccine works in a different way, and the preliminary studies in mice have shown none of the previous side effects.

More research is being done to see if this can be taken forward into humans. Let’s hope so!

You can check out the original journal article:
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9619-24. Epub 2006 Jun 12
Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety.
Okura Y, Miyakoshi A, Kohyama K, Park IK, Staufenbiel M, Matsumoto Y.

or a BBC article written on it:
http://news.bbc.co.uk/1/hi/health/5071036.stm

posted by Kristina Cook at 12:45 PM  

About the author

Kristina Cook Name: Kristina Cook

Location: Oxford, United Kingdom


My name is Kristina Cook and I am a first year DPhil (PhD) student in a mix of Chemistry/Biochemistry and Pharmacology at Oxford University. I am 23 years old. I just moved to Oxford from Washington DC, where I lived for two months as part of the graduate program I am in. Before this I had lived in San Diego, California for five years where I went to San Diego State University for my undergraduate education. In those five years I had the opportunity to further my science education by working for a wonderful small biotech/pharmaceutical company for three years, in the in-vitro pharmacology department. I also worked in an academic lab in synthetic chemistry, for two years. I am now out in Oxford, researching cancer angiogenesis, specifically some of the proteins involved, and looking for potential new ways of treating cancer.

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This page has been set up to promote scientific research and show support for animal research conducted ethically and intelligently. Recent news in science, discussions on science and animal research and guest writings by fellow scientists are just a few of the things you can expect to find here. Build the Oxford Lab!

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Click to Give a Free Mammogram to a Woman in Need
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Alzheimer's Vaccine from Mice!?
New Web Address for Stand Up For Science
Whew! More Human Lives Saved by Mice!!
New Web Address for Stand Up For Science
"New” breast-cancer drug progresses to human trials
Macaque Studies Find Potential AIDS Preventative Treatment
Recent Breakthrough in Medicine Thanks to Animal Research!
Why Animal Research is Important AND Needed: A Copy of the Speech I Gave on the February 25th Demonstration
Facts about Animal Research
The Dawn of a New Age: Standing up, Proud and Tall, For Animal Research and The Oxford Lab

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